Hardy P
Univ Paris-Sud, U669, Le Kremlin Bicêtre, F-94276 ; AP-HP, Le Kremlin-Bicêtre, F-94275.
Encephale. 2009 Dec;35 Suppl 7:S269-71. doi: 10.1016/S0013-7006(09)73484-0.
The severity of depression is related to its clinical features and also its impact in terms of morbidity and mortality. Depression is the most common psychiatric disorders associated with suicide and is found in almost one out of two cases, in 85% of situations associated with another mental disorder. Clinically severe depression also has a 4 to 5 times higher long term risk of suicide than mild or moderate depression. Severe depression is also associated with significantly increased deaths from natural causes : in absolute terms this is similar to the additional mortality rate from suicide. Cardiovascular diseases, particularly coronary, are a particular feature of this increased cause of natural deaths. These findings justify the development of prevention and screening for these diseases in depressed patients.
抑郁症的严重程度与其临床特征相关，也与其在发病率和死亡率方面的影响有关。抑郁症是与自杀相关的最常见精神疾病，几乎每两例自杀案例中就有一例与之相关，在85%的情况下还与另一种精神障碍有关。临床上，重度抑郁症的长期自杀风险比轻度或中度抑郁症高4至5倍。重度抑郁症还与自然原因导致的死亡显著增加有关：从绝对值来看，这与自杀导致的额外死亡率相似。心血管疾病，尤其是冠心病，是自然死亡增加原因中的一个特别特征。这些发现为在抑郁症患者中开展这些疾病的预防和筛查提供了依据。
