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阻断 NMDA 受体在中风中的致命作用。

Blocking the deadly effects of the NMDA receptor in stroke.

机构信息

Brain Research Centre, Vancouver Coastal Health Research Institute and University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada.

出版信息

Cell. 2010 Jan 22;140(2):174-6. doi: 10.1016/j.cell.2010.01.014.

DOI:10.1016/j.cell.2010.01.014
PMID:20141829
Abstract

Excessive activation of NMDA glutamate receptors contributes to neuronal death after stroke. In this issue, Tu et al. (2010) demonstrate that ischemic injury promotes the association of death-associated protein kinase 1 with the NMDA receptor, thereby potentiating its activity, and show that disrupting this association reduces damage to the brain.

摘要

过度激活 NMDA 谷氨酸受体是中风后神经元死亡的原因之一。在本期杂志中，Tu 等人（2010）表明，缺血性损伤促进了死亡相关蛋白激酶 1 与 NMDA 受体的结合，从而增强了其活性，并表明破坏这种结合可以减少对大脑的损伤。

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