睡眠呼吸紊乱与心力衰竭：聚焦阻塞性睡眠呼吸暂停及持续气道正压通气治疗。
Sleep-disordered breathing and heart failure: focus on obstructive sleep apnea and treatment with continuous positive airway pressure.
机构信息
Department of Internal Medicine, Emory University, Atlanta, GA, USA.
出版信息
J Card Fail. 2010 Feb;16(2):164-74. doi: 10.1016/j.cardfail.2009.08.006. Epub 2009 Oct 28.
BACKGROUND
Among patients with heart failure, sleep-disordered breathing is a common problem, with a prevalence ranging from 24% to 76%. Encompassed within the general category of sleep-disordered breathing are 2 types of sleep apnea: obstructive sleep apnea (OSA) occurs when the oropharyngeal musculature relaxes, causing a collapse of the upper airway, and central sleep apnea occurs when the brain stem fails to stimulate breathing.
METHODS AND RESULTS
This article focuses on the relationship between heart failure and OSA, the treatment of OSA with continuous positive airway pressure (CPAP), and the role of CPAP in improving such effects of heart failure as ejection fraction, blood pressure, sympathetic activity, sleepiness, heart rate, and mortality.
CONCLUSIONS
It is important to distinguish the type of sleep-disordered breathing a patient may have. Further studies are needed to elucidate the effects of CPAP and other therapies.
背景
心力衰竭患者中，睡眠呼吸紊乱是一种常见问题，其患病率为 24%至 76%不等。睡眠呼吸紊乱一般包括 2 种类型的睡眠呼吸暂停：当口咽肌肉松弛时，会发生阻塞性睡眠呼吸暂停（OSA），导致上呼吸道塌陷；而中枢性睡眠呼吸暂停则是由于脑干未能刺激呼吸而发生。
方法和结果
本文重点关注心力衰竭与 OSA 的关系、持续气道正压通气（CPAP）治疗 OSA 以及 CPAP 在改善射血分数、血压、交感神经活性、嗜睡、心率和死亡率等心力衰竭效应方面的作用。
结论
区分患者可能存在的睡眠呼吸紊乱类型很重要。需要进一步研究来阐明 CPAP 和其他治疗方法的效果。
Zotero 插件