Petroski Matthew D
Signal Transduction Program, NCI Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Chem Biol. 2010 Jan 29;17(1):6-8. doi: 10.1016/j.chembiol.2010.01.002.
Brownell et al. (2010) elucidate the mechanism of action of MLN4924, a NEDD8-activating enzyme inhibitor. MLN4924 requires the activity of the enzyme to generate a NEDD8-adenylate analog that potently and selectively shuts down this posttranslational modification system.
布朗内尔等人（2010年）阐明了NEDD8激活酶抑制剂MLN4924的作用机制。MLN4924需要该酶的活性来生成一种NEDD8-腺苷酸类似物，这种类似物能有效且选择性地关闭这种翻译后修饰系统。
