University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
Cell Metab. 2010 Feb 3;11(2):95-6. doi: 10.1016/j.cmet.2010.01.006.
BRS-3 is an orphan G protein coupled receptor highly expressed in the brain. Pharmacological studies in this issue (Guan et al., 2010) further support a role for this receptor in energy homeostasis and show that the BRS-3 agonist Bag-1 effectively causes weight loss by decreasing food intake and increasing metabolic rate.
BRS-3 是一种孤儿 G 蛋白偶联受体，在大脑中高度表达。本期杂志中的药理学研究（Guan 等人，2010）进一步支持了该受体在能量平衡中的作用，并表明 BRS-3 激动剂 Bag-1 通过减少食物摄入和增加代谢率有效地导致体重减轻。
