Hansl N R, Zarlengo D G
Clin Toxicol. 1977;11(4):427-35. doi: 10.3109/15563657708988206.
It was found that the effect of isoproterenol on the vasculature of the anesthetized dog can be potentiated by previous administration of papaverine. This effect is apparent in spite of concomitant potentiation of inotropic and/or chronotropic effects, which tend to obscure the vasomotor effect. Evidence is presented supporting the hypothesis that papaverine interacts with receptors of the vascular tree, which are usually classified as beta receptors and are responsive to isoproterenol. Evidence is presented showing almost complete inhibition of the chronotropic effects of papaverine by propranolol, and a synergism of papaverine with the chronotropic effects of isoproterenol. Evidence was obtained using the intestinal smooth muscle of the rabbit in support of the hypothesis linking mediation of the beta adrenergic system to papaverine effects.
研究发现，预先给予罂粟碱可增强异丙肾上腺素对麻醉犬血管系统的作用。尽管同时增强了心肌收缩力和/或心率作用，这些作用往往会掩盖血管运动效应，但这种增强血管作用的效果仍然明显。有证据支持这样的假说，即罂粟碱与血管树的受体相互作用，这些受体通常被归类为β受体，对异丙肾上腺素敏感。有证据表明，普萘洛尔几乎完全抑制了罂粟碱的心率作用，且罂粟碱与异丙肾上腺素的心率作用具有协同作用。利用兔的肠道平滑肌获得的证据支持了将β肾上腺素能系统的介导与罂粟碱作用联系起来的假说。
