Turkoski Beatrice B
Kent State University College of Nursing, Kent, OH, USA.
Orthop Nurs. 2010 Jan-Feb;29(1):41-3; quiz 44-5. doi: 10.1097/NOR.0b013e3181c8cd75.
Acetaminophen is an old and comfortable friend. In its over-the-counter forms (of which there are almost 100), it is used by millions of people for relief of pain and to treat mild fevers. When combined with an opioid as a prescription drug, it is often effective for more severe pain. Generally, for most people, when taken as directed, acetaminophen has proved to be not only effective but also safe with very few adverse effects. However, the relationship between acetaminophen use and acute liver damage is not as well known (despite Federal Drug Administration [FDA] recommendations for changes that relate to both labeling and use). In this article, recent moves by the FDA to make acetaminophen safety are discussed. Nurses who are able to educate their patients about the safety issues related to acetaminophen will be very important in reducing the incidence of overdose-related liver failure.
对乙酰氨基酚是一位熟悉且常用的老朋友。其非处方形式（种类近百种）被数百万人用于缓解疼痛和治疗轻度发热。当与阿片类药物联合作为处方药使用时，它通常对更严重的疼痛有效。一般来说，对大多数人而言，按指示服用时，对乙酰氨基酚已被证明不仅有效，而且安全性高，副作用极少。然而，对乙酰氨基酚的使用与急性肝损伤之间的关系并不广为人知（尽管美国食品药品监督管理局[FDA]针对标签和使用方面的变更提出了建议）。本文讨论了FDA近期为提高对乙酰氨基酚安全性所采取的举措。能够就与对乙酰氨基酚相关的安全问题对患者进行教育的护士，对于降低过量用药导致的肝衰竭发生率将非常重要。
