Deray G, Cacoub P, Jacquiaud C, Drobinski G, Brillet G, Bunker D, Jaudon M C, Jacobs C
Department of Nephrology, Hôpital Pitie-Salpetriere, Paris, France.
Radiology. 1991 May;179(2):395-7. doi: 10.1148/radiology.179.2.2014280.
The authors sought to evaluate renal tolerance for ioxaglate sodium meglumine used as a contrast agent in patients with chronic renal failure. Eight male patients (mean age, 55 years +/- 5) with chronic renal insufficiency (glomerular filtration rate less than 60 mL/min) who underwent diagnostic cardiac catheterization were enrolled. Renal clearance of inulin and rho-aminohippuric acid and urinary enzyme excretion were studied 1 day before and 1 day after administration of 167 mL +/- 43 of ioxaglate. None of the patients experienced any adverse reactions. All the patients had markedly depressed renal clearance values before angiography. Mean serum creatinine level, glomerular filtration rate, effective renal plasma flow, and urinary beta 2-microglobulin excretion were unaltered by angiography. After the procedure, only one patient had an increase in serum creatinine level of more than 10% (from 115 to 159 mumol/L [1.3 to 1.8 mg/dL]), with a decrease in glomerular filtration rate from 34 to 27 mL/min. In this patient, serum creatinine level and glomerular filtration rate normalized within 72 hours. Using accurate and sensitive renal function tests, the authors have shown that ioxaglate may be used safely in patients with chronic renal failure.
作者试图评估在慢性肾衰竭患者中使用碘克沙醇葡甲胺作为造影剂时的肾脏耐受性。纳入了8名接受诊断性心导管插入术的男性慢性肾功能不全患者（平均年龄55岁±5岁，肾小球滤过率低于60 mL/min）。在给予167 mL±43碘克沙醇之前1天和之后1天，研究了菊粉和对氨基马尿酸的肾清除率以及尿酶排泄情况。所有患者均未出现任何不良反应。所有患者在血管造影术前肾清除率值均显著降低。血管造影术对平均血清肌酐水平、肾小球滤过率、有效肾血浆流量和尿β2-微球蛋白排泄均无影响。术后，只有1例患者血清肌酐水平升高超过10%（从115升至159 μmol/L [1.3至1.8 mg/dL]），肾小球滤过率从34降至27 mL/min。该患者的血清肌酐水平和肾小球滤过率在72小时内恢复正常。通过使用准确且灵敏的肾功能测试，作者表明碘克沙醇可安全用于慢性肾衰竭患者。
