Karolinska Institutet, SE-171-77, Stockholm, Sweden.
World J Surg. 2010 Apr;34(4):684-91. doi: 10.1007/s00268-010-0430-7.
The aim of the study was to compare the changes in health-related quality of life (QOL) after lung surgery between young and old patients.
We performed a prospective, population-based, cohort study to investigate health-related QOL before and 6 months after lung surgery. We used the validated instrument Short Form-36 (SF-36), to investigate QOL. The main outcome measures were fractional change in the SF-36 physical (DeltaPCS%) and mental (DeltaMCS%) component summary scores. We also compared the two age groups to age- and sex-matched reference populations.
We included 249 patients: 166 young (<70 years) and 83 old (> or =70 years) patients. The overall response rate at 6 months was 84%. There was no significant difference in the primary outcome measures between young and old patients (DeltaPCS% -13 vs. -16, p = 0.55; DeltaMCS% 9 vs. 1, p = 0.22). The 2-year survivals (mean follow-up 2.1 years) were 83% and 84% in young and old patients, respectively (p = 0.72). In both groups, physical and mental QOL were lower than in the reference populations.
We found that at 6 months after lung surgery old patients experienced deterioration in physical and mental health-related QOL similar to that of young patients. Survival also was similar in the two groups.
本研究旨在比较年轻和老年患者肺手术后健康相关生活质量（QOL）的变化。
我们进行了一项前瞻性、基于人群的队列研究，以调查肺手术后 6 个月前和后的健康相关 QOL。我们使用经过验证的短表 36（SF-36）工具来调查 QOL。主要观察指标是 SF-36 生理（DeltaPCS%）和心理（DeltaMCS%）成分综合评分的分数变化。我们还将这两个年龄组与年龄和性别匹配的参考人群进行了比较。
我们纳入了 249 名患者：166 名年轻（<70 岁）和 83 名老年（>=70 岁）患者。6 个月时的总体应答率为 84%。年轻和老年患者的主要结局指标无显著差异（DeltaPCS%-13 与-16，p=0.55；DeltaMCS%9 与 1，p=0.22）。2 年生存率（平均随访 2.1 年）分别为年轻和老年患者的 83%和 84%（p=0.72）。在两组中，身体和心理健康相关 QOL 均低于参考人群。
我们发现，在肺手术后 6 个月时，老年患者在身体和心理健康相关 QOL 方面的恶化与年轻患者相似。两组的生存率也相似。
