Department of Neurology, Danish Headache Centre, Glostrup Hospital, University of Copenhagen, Glostrup, Copenhagen, Denmark.
J Headache Pain. 2010 Apr;11(2):93-5. doi: 10.1007/s10194-010-0190-7. Epub 2010 Feb 9.
Inhalation of hyperbaric oxygen has been used as an experimental treatment for migraine and pure oxygen is an established treatment for cluster headache. Intravenous glyceryl trinitrate (GTN) is an established headache model. In the present study the possibility of decreasing the headache by inhalation of pure oxygen was explored in a double-blind crossover design in 18 healthy subjects. Inhalation of air served as placebo. The subjects received intravenous GTN (0.25 microg/kg/min) for 20 min. Headache was scored for 85 min. Sixteen of 18 (89%) subjects experienced GTN-induced headache after O(2)-inhalation and 17/18 (94%) experienced GTN-induced headache after air. The mean peak headache scores were 1.9 and 2.4, respectively, on a numerical scale of 0-10. Oxygen inhalation did not have effect on GTN-induced headache, most likely because the theoretical decrease in NO levels, due to faster metabolism of NO, is too small to be detected in the GTN headache model.
高压氧吸入已被用作偏头痛的实验治疗方法，而纯氧是治疗丛集性头痛的既定方法。静脉内甘油三硝酸酯（GTN）是一种已确立的头痛模型。在本研究中，18 名健康受试者采用双盲交叉设计，探索了吸入纯氧是否可以减轻头痛。空气吸入作为安慰剂。受试者接受静脉内 GTN（0.25 微克/千克/分钟）输注 20 分钟。头痛评分持续 85 分钟。18 名受试者中有 16 名（89%）在吸入 O2 后出现 GTN 诱导的头痛，17 名（94%）在吸入空气后出现 GTN 诱导的头痛。数字评分量表上的平均峰值头痛评分分别为 1.9 和 2.4（0-10）。氧吸入对 GTN 诱导的头痛没有影响，最可能的原因是由于 NO 代谢更快，导致的 NO 水平理论下降太小，在 GTN 头痛模型中无法检测到。
