Shvarts V
Klin Med (Mosk). 2009;87(11):17-24.
The aim of this clinico-epidemiological study was to elucidate the role of postprandial hyperglycemia (PH) and high glucose level 2 hours after glucose load in the development of cardiovascular disorders (CDD) in patients with type 2 diabetes mellitus and in the general population. Medical interventions to reduce PH decrease the risk of CDD. Pathophysiological studies show the involvement of oxidative stress in pathogenesis of CDD in cases with PH. Acute hyperglycemia increases heart rate and arterial pressure, disturbs myocardial perfusion and contractility, causes endothelial dysfuncton and atherosclerosis. The following preparations are recommended to subjects with DM2 and PH: alpha-glucosidase inhibitors, glynides, ultrashort-acting insulin analogs, dipeptidylpeptidase-4 inhibitors, exenatide (incretin mimetic).
这项临床流行病学研究的目的是阐明餐后高血糖（PH）以及葡萄糖负荷后2小时的高血糖水平在2型糖尿病患者和普通人群心血管疾病（CDD）发生发展中的作用。降低PH的医学干预措施可降低CDD风险。病理生理学研究表明，在存在PH的情况下，氧化应激参与了CDD的发病机制。急性高血糖会增加心率和动脉压，扰乱心肌灌注和收缩力，导致内皮功能障碍和动脉粥样硬化。建议患有2型糖尿病和PH的受试者使用以下制剂：α-葡萄糖苷酶抑制剂、格列奈类、超短效胰岛素类似物、二肽基肽酶-4抑制剂、艾塞那肽（肠促胰岛素类似物）。
