Madsbad Sten, Brock Birgitte, Schmitz Ole
H:S Hvidovre Hospital, Medicinsk Center, Endokrinologisk Klinik, DK-2650 Hvidovre.
Ugeskr Laeger. 2003 Aug 11;165(33):3149-53.
Epidemiological studies have suggested that postprandial hyperglycaemia may be a unique risk factor for development of cardiovascular disease, although the predictive value has been minor or disappeared after compensation for other cardiovascular risk factors. Pathophysiological studies have demonstrated that acute changes in blood glucose may induce changes predisposing for development of microangiopathy in the retina, the kidneys and the nerves. Studies have also shown that postprandial hyperglycaemia may be a risk factor for the development of atherosclerosis. No randomised controlled trials have focused on specific treatment of postprandial hyperglycaemia. Therefore, the importance of postprandial hyperglycaemia for development of diabetic complications and atherosclerosis is unclear.
流行病学研究表明，餐后高血糖可能是心血管疾病发生的一个独特危险因素，尽管在对其他心血管危险因素进行校正后，其预测价值较小或消失。病理生理学研究表明，血糖的急性变化可能诱发视网膜、肾脏和神经微血管病变发展的易患性改变。研究还表明，餐后高血糖可能是动脉粥样硬化发生的一个危险因素。尚无随机对照试验聚焦于餐后高血糖的特异性治疗。因此，餐后高血糖对糖尿病并发症和动脉粥样硬化发生的重要性尚不清楚。
