Scheen A J, Radermecker R P
Université de Liège.
Rev Med Liege. 2009 Dec;64(12):606-11.
Ezetimibe (Ezetrol) selectively inhibits the intestinal absorption of cholesterol and phytosterols. Its mechanism of action results in a synergistic cholesterol-lowering effect together with a statin that inhibits cholesterol synthesis by the liver, which leads to the development of a fixed ezetimibe-simvastatin combination (Inegy). Ezetimibe has been more particularly studied in patients with type 2 diabetes whose high cardiovascular risk is well known. The present article aims at describing recent advances and specificities concerning the use of ezetimibe in the diabetic population.
依折麦布(益适纯)可选择性抑制肠道对胆固醇及植物甾醇的吸收。其作用机制可与抑制肝脏胆固醇合成的他汀类药物产生协同降胆固醇效应,进而促成了固定剂量的依折麦布-辛伐他汀复方制剂(可定)的研发。依折麦布在心血管疾病高风险的2型糖尿病患者中得到了更深入的研究。本文旨在阐述依折麦布在糖尿病患者群体中应用的最新进展及特性。