El-Chemaly Souheil, Pacheco-Rodriguez Gustavo, Ikeda Yoshihiko, Malide Daniela, Moss Joel
Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1590, USA.
Lymphat Res Biol. 2009 Dec;7(4):197-203. doi: 10.1089/lrb.2009.0014.
The lymphatic vasculature plays a key role in tissue homeostasis and immune surveillance. There is mounting evidence of a role for the lymphatic circulation and for newly formed lymphatic vessels in the pathogenesis of lung disease. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, debilitating lung disease. In IPF, the lung parenchyma undergoes extensive remodeling. This review focuses on the current knowledge and understanding of the pathogenesis of IPF, and recent evidence of the involvement of lymphangiogenesis in lung injury and repair and the molecular and cellular pathways leading to the development of lymphatic vasculature.
淋巴脉管系统在组织稳态和免疫监视中起关键作用。越来越多的证据表明，淋巴循环和新形成的淋巴管在肺部疾病的发病机制中发挥作用。特发性肺纤维化（IPF）是一种慢性、进行性、使人衰弱的肺部疾病。在IPF中，肺实质会发生广泛的重塑。本综述聚焦于目前对IPF发病机制的认识和理解，以及淋巴管生成参与肺损伤和修复的最新证据，以及导致淋巴脉管系统发育的分子和细胞途径。
