Department of Urology, Nagano Red Cross Hospital, Japan.
Aging Male. 2010 Sep;13(3):166-73. doi: 10.3109/13685530903536684.
In addition to hormone replacement therapy, non-hormonal therapy, particularly Japanese traditional herbal medicine (Kampo), has been used to alleviate the various symptoms of female menopause. The efficacy and safety of Japanese traditional herbal medicine for male late-onset hypogonadism (LOH) are investigated.
One hundred fifty-one patients with LOH were treated via the administration of Japanese traditional herbal medicine. The most appropriate Japanese traditional herbal medicine was administered to patients according to their pathogenic alteration. After 4 weeks, the clinical efficacy was evaluated based on improvement of LOH symptoms and the score of the simplified menopausal index (SMI). Additionally, predictive factors of efficacy of Japanese traditional herbal medicine were analyzed.
Among 151 patients with LOH, 63 (41.8%) achieved both relief from LOH symptoms and normalized SMI score (Excellent response group), whereas 44 (29.1%) achieved either relief from LOH symptoms or normalized SMI score (Fair). However, 44 (29.1%) patients displayed neither relief from LOH symptoms nor normalized SMI score (Poor). Adverse reactions were observed only in four (2.6%) patients. Patients displaying excess conditions and mild LOH symptoms appeared to be superior candidates for Japanese traditional herbal medicine.
Japanese traditional herbal medicine is an effective and safe treatment for LOH.
除激素替代疗法外，非激素疗法，特别是日本传统草药（汉方药），已被用于缓解女性更年期的各种症状。本研究旨在探讨日本传统草药治疗男性迟发性性腺功能减退症（LOH）的疗效和安全性。
151 例 LOH 患者接受日本传统草药治疗。根据患者的病因变化，为患者选择最合适的日本传统草药。4 周后，根据 LOH 症状改善和简化绝经指数（SMI）评分评估临床疗效。此外，还分析了日本传统草药疗效的预测因素。
在 151 例 LOH 患者中，63 例（41.8%）既缓解了 LOH 症状，又使 SMI 评分正常（优效组），44 例（29.1%）缓解了 LOH 症状或 SMI 评分正常（中效）。然而，44 例（29.1%）患者既未缓解 LOH 症状，也未使 SMI 评分正常（差）。仅 4 例（2.6%）患者出现不良反应。表现为实证和轻度 LOH 症状的患者似乎更适合接受日本传统草药治疗。
日本传统草药是治疗 LOH 的一种有效且安全的方法。
