Clinic for Orthopedics and Traumatology, University Central Hospital, Helsinki, Finland.
Scand J Rheumatol. 1987;16(1):22-9. doi: 10.3109/03009747009165352.
The aim of the study was to elucidate histological changes provoked by Mycobacterium butyricum toxine in the rat joints, stomach, small intestine and thymus and the uptake of tritiated thymidine. Freund's complete adjuvant was injected into the base of the vastus muscle of 35 rats; 21 rats served as controls. Fifteen rats displayed histologically mild synovitis in the ankle joint, two periostitis and three muscle infiltrates. Histological study revealed no difference between the test animals and the controls in the stomach, small intestine and thymus. The thymidine uptake of the adjacent growth lines of the knee, stomach mucosa, small intestine, spleen and liver was the same in both groups. In contrast, the uptake of the cells of the thymus was smaller in the adjuvant-treated rats with a probability of over 90 per cent. This suggests that the mitosis of adjuvant-induced thymic cells is smaller than in cells with a normal condition.
本研究旨在阐明丁酸分枝杆菌毒素在大鼠关节、胃、小肠和胸腺引起的组织学变化，以及氚标记胸腺嘧啶核苷的摄取情况。弗氏完全佐剂被注入 35 只大鼠的股四头肌底部；21 只大鼠作为对照。15 只大鼠踝关节出现组织学上轻度滑膜炎，2 只大鼠出现骨膜炎，3 只大鼠出现肌肉浸润。组织学研究显示，在胃、小肠和胸腺方面，实验组和对照组之间没有差异。两组膝关节、胃黏膜、小肠、脾脏和肝脏的相邻生长线的胸腺嘧啶核苷摄取量相同。相比之下，佐剂处理大鼠的胸腺细胞摄取量较小，概率超过 90%。这表明，佐剂诱导的胸腺细胞的有丝分裂比正常情况下的细胞要小。
