Manu P, Matthews D A, Lane T J
Department of Medicine, University of Connecticut School of Medicine, Farmington 06032.
South Med J. 1991 Apr;84(4):451-6. doi: 10.1097/00007611-199104000-00010.
Among 200 adults with a chief complaint of chronic fatigue evaluated in an internal medicine practice, currently active panic disorder was diagnosed in 26 patients (13%), a frequency tenfold greater than that in the general population. Panic disorder preceded or was coincidental with the onset of chronic fatigue in 21 of these patients. In comparison with the rest of the study cohort, significantly more patients with panic disorder had a history of severe depression, including persistent thoughts of death or suicide. Moreover, more patients with panic disorder showed a lifetime tendency to have physical symptoms that remained unexplained after medical evaluation. Our findings suggest that treatable panic disorder is an important contributor not only to major depression and somatization, but also to the etiology and clinical presentation of chronic fatigue in patients in an outpatient practice.
在内科诊所接受评估的200名以慢性疲劳为主诉的成年人中，26名患者（13%）被诊断为当前处于活动期的惊恐障碍，其发生率是普通人群的10倍。在这些患者中，21名患者的惊恐障碍先于慢性疲劳发作或与之同时出现。与研究队列中的其他患者相比，患有惊恐障碍的患者有严重抑郁症病史的明显更多，包括持续的死亡或自杀念头。此外，更多患有惊恐障碍的患者表现出终生存在身体症状的倾向，这些症状在医学评估后仍无法解释。我们的研究结果表明，可治疗的惊恐障碍不仅是重度抑郁症和躯体化的重要促成因素，也是门诊患者慢性疲劳的病因和临床表现的重要促成因素。
