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N Engl J Med. 2008 Nov 20;359(21):2220-32. doi: 10.1056/NEJMoa0801869.
2
Genotype score in addition to common risk factors for prediction of type 2 diabetes.除常见风险因素外，基因型评分对2型糖尿病的预测作用
N Engl J Med. 2008 Nov 20;359(21):2208-19. doi: 10.1056/NEJMoa0804742.
3
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.全基因组关联数据的荟萃分析及大规模重复研究确定了2型糖尿病的其他易感基因座。
Nat Genet. 2008 May;40(5):638-45. doi: 10.1038/ng.120. Epub 2008 Mar 30.
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Genome-wide association with diabetes-related traits in the Framingham Heart Study.弗雷明汉心脏研究中与糖尿病相关性状的全基因组关联研究。
BMC Med Genet. 2007 Sep 19;8 Suppl 1(Suppl 1):S16. doi: 10.1186/1471-2350-8-S1-S16.
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Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.对10705名丹麦受试者中HHEX、CDKN2A/B和IGF2BP2基因附近变异与2型糖尿病及胰岛素释放受损的关联性研究：全基因组关联研究的验证与扩展
Diabetes. 2007 Dec;56(12):3105-11. doi: 10.2337/db07-0856. Epub 2007 Sep 7.
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The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians.TCF7L2基因的rs12255372（G/T）和rs7903146（C/T）多态性与亚洲印度人的2型糖尿病相关。
Metabolism. 2007 Sep;56(9):1174-8. doi: 10.1016/j.metabol.2007.04.012.
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Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women.TCF7L2基因的常见变异与英国欧洲白人、印度亚洲人和非洲加勒比男性及女性的2型糖尿病易感性
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8
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Nature. 2007 Jun 7;447(7145):661-78. doi: 10.1038/nature05911.
9
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.一项针对芬兰人2型糖尿病的全基因组关联研究发现了多个易感变异体。
Science. 2007 Jun 1;316(5829):1341-5. doi: 10.1126/science.1142382. Epub 2007 Apr 26.
10
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.全基因组关联分析确定2型糖尿病和甘油三酯水平的基因座。
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美国空军人员2型糖尿病的基因组学研究。

A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.

作者信息

Lott Lisa

机构信息

Advanced Diagnostic Laboratory, Lackland Air Force Base, Texas 78236, USA.

出版信息

J Diabetes Sci Technol. 2009 Jul 1;3(4):770-5. doi: 10.1177/193229680900300425.

DOI:10.1177/193229680900300425
PMID:20144327
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2769956/
Abstract

The military community is at high risk for type 2 diabetes (T2D), especially as it relates to military beneficiaries, although preventive measures can be implemented to reduce disease onset. This study evaluates the prevalence of risk-associated single nucleotide polymorphisms in patients diagnosed with T2D within active duty, retired military, and military-dependent populations on Lackland Air Force Base compared to nondiabetic controls. Results will be used as a basis of comparison to analyze risk-conferring genotypes in the young, healthy active duty population to generate the prevalence of T2D risk-associated factors in our current and future war fighters. Identifying genetic markers of T2D prior to abnormal glucose control and insulin resistance may ultimately adjust future risk through early detection, healthy lifestyle modifications, and disease management programs.

摘要

军事群体患2型糖尿病（T2D）的风险很高，尤其是涉及军事受益人的情况，不过可以采取预防措施来降低疾病的发生。本研究评估了与风险相关的单核苷酸多态性在拉克兰空军基地现役、退役军人及军属人群中被诊断为T2D的患者中的流行情况，并与非糖尿病对照组进行比较。研究结果将作为比较的基础，用于分析年轻、健康的现役人群中赋予风险的基因型，以得出我们当前及未来作战人员中T2D风险相关因素的流行情况。在血糖控制异常和胰岛素抵抗出现之前识别T2D的遗传标记，最终可能通过早期检测、健康生活方式调整和疾病管理计划来调整未来风险。