Klonoff David C
Mills-Peninsula Health Services, San Mateo, California 94401, USA.
J Diabetes Sci Technol. 2009 Jul 1;3(4):677-9. doi: 10.1177/193229680900300410.
Personalized medicine for diabetes is a potential method to specifically identify people who are at high risk of developing type 2 diabetes based on a combination of personal history, family history, physical examination, circulating biomarkers, and genome. High-risk individuals can then be referred to lifestyle programs for risk reduction and disease prevention. Using a personalized medicine approach, a patient with already-diagnosed type 2 diabetes can be treated individually based on information specific to that individual. The field of personalized medicine for diabetes is rapidly exploding. Diabetes Technology Society convened the Personalized Medicine for Diabetes (PMFD) Meeting March 19-20, 2009 in San Francisco. The meeting was funded through a contract from the US Air Force. Diabetes experts from the military, government, academic, and industry communities participated. The purpose was to reach a consensus about PMFD in type 2 diabetes to (a) establish screening programs, (b) diagnose cases at an early stage, and (c) monitor and treat the disease with specific measures. The group defined what a PMFD program should encompass, what the benefits and drawbacks of such a PMFD program would be, and how to overcome barriers. The group reached six conclusions related to the power of PMFD to improve care of type 2 diabetes by resulting in (1) better prediction, (2) better prophylactic interventions, (3) better treatments, and (4) decreased cardiovascular disease burden. Additional research is needed to demonstrate the benefits of this approach. The US Air Force is well positioned to conduct research and develop clinical programs in PMFD.
糖尿病个性化医疗是一种潜在的方法,可基于个人病史、家族病史、体格检查、循环生物标志物和基因组等综合因素,特异性地识别出有患2型糖尿病高风险的人群。然后,可将高风险个体转介至生活方式干预项目,以降低风险和预防疾病。采用个性化医疗方法,已确诊2型糖尿病的患者可根据其个人特定信息进行个体化治疗。糖尿病个性化医疗领域正在迅速发展。糖尿病技术协会于2009年3月19日至20日在旧金山召开了糖尿病个性化医疗(PMFD)会议。该会议由美国空军的一项合同资助。来自军队、政府、学术界和工业界的糖尿病专家参与其中。目的是就2型糖尿病的PMFD达成共识,以(a)建立筛查项目,(b)早期诊断病例,以及(c)用特定措施监测和治疗该疾病。该小组明确了PMFD项目应涵盖的内容、此类PMFD项目的利弊以及如何克服障碍。该小组得出了与PMFD通过实现(1)更好的预测、(2)更好的预防性干预、(3)更好的治疗以及(4)减轻心血管疾病负担来改善2型糖尿病护理的能力相关的六项结论。需要进一步的研究来证明这种方法的益处。美国空军在开展PMFD研究和开发临床项目方面具有良好的条件。