Department of Radiology, Diagnostic Imaging Center, Sendai Seiryo Clinic, Sendai, Japan.
Atherosclerosis. 2010 Jun;210(2):674-7. doi: 10.1016/j.atherosclerosis.2010.01.008. Epub 2010 Jan 22.
High levels of serum cholesterol are associated with the risk of stroke. However, the association of serum cholesterol with silent brain infarcts (SBIs) is unclear. We investigated the association between SBI and various clinical factors.
We conducted a cross-sectional study that included 324 apparently healthy Japanese men (mean age 53.8+/-9.2 years). Combinations of three types of scan (T1-weighted, T2-weighted and FLAIR images) were used to detect and discriminate SBI.
Serum cholesterol was significantly associated with SBI [total cholesterol, odds ratio (OR) 3.75 (95% confidence interval (CI) 1.45-9.68); LDL-cholesterol, OR 2.54 (95% CI 1.03-6.27), and non-HDL-cholesterol, OR 2.54 (95% CI 1.03-6.27)] after adjustment for age, smoking status, serum triglycerides, maximal-intima-media thickness, obesity, hypertension, diabetes mellitus, hyperuricemia, coronary heart disease and lipid-lowering agent use.
Our cross-sectional data suggest that serum cholesterol levels are associated with SBI independently of known confounders.
血清胆固醇水平升高与中风风险相关。然而，血清胆固醇与无症状性脑梗死（SBIs）之间的关系尚不清楚。我们研究了 SBI 与各种临床因素之间的关系。
我们进行了一项横断面研究，纳入了 324 名看似健康的日本男性（平均年龄 53.8+/-9.2 岁）。使用三种扫描类型（T1 加权、T2 加权和 FLAIR 图像）的组合来检测和区分 SBI。
校正年龄、吸烟状况、血清甘油三酯、最大内膜中层厚度、肥胖、高血压、糖尿病、高尿酸血症、冠心病和降脂药使用后，血清胆固醇与 SBI 显著相关[总胆固醇，比值比（OR）3.75（95%置信区间（CI）1.45-9.68）；低密度脂蛋白胆固醇，OR 2.54（95% CI 1.03-6.27）和非高密度脂蛋白胆固醇，OR 2.54（95% CI 1.03-6.27）]。
我们的横断面数据表明，血清胆固醇水平与 SBI 独立于已知混杂因素相关。
