基质金属蛋白酶-9 多态性与台湾女性盆腔器官脱垂风险的关系。
Matrix metalloproteinase-9 polymorphism and risk of pelvic organ prolapse in Taiwanese women.
机构信息
Department of Obstetrics and Gynecology, China Medical University Hospital, Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2010 Apr;149(2):222-4. doi: 10.1016/j.ejogrb.2009.12.014. Epub 2010 Feb 7.
OBJECTIVE
Matrix metalloproteinase-9 is known to play an important role in the pathophysiology of pelvic organ prolapse. We investigated whether the matrix metalloproteinase-9 gene polymorphisms were associated with pelvic organ prolapse by conducting a case-control association study in 92 women with pelvic organ prolapse and 152 women without pelvic organ prolapse.
STUDY DESIGN
Genotypes of the matrix metalloproteinase-9 gene polymorphisms (rs3918242, rs17576, and rs2250889) were determined by polymerase chain reaction, followed by restriction fragment length polymorphism analysis.
RESULTS
There was significant difference between women with and without pelvic organ prolapse in the distribution of the matrix metalloproteinase-9 rs17576 genotypes evaluated. Using multivariable logistic regression, menopausal status, matrix metalloproteinase-9 rs17576 genotype AG, and matrix metalloproteinase-9 rs17576 genotype GG were significantly associated with pelvic organ prolapse.
CONCLUSION
The present study shows that the polymorphism of matrix metalloproteinase-9 rs17576 may be associated with pelvic organ prolapse.
目的
已知基质金属蛋白酶-9 在盆腔器官脱垂的病理生理学中发挥重要作用。我们通过对 92 例盆腔器官脱垂患者和 152 例无盆腔器官脱垂患者进行病例对照关联研究，探讨基质金属蛋白酶-9 基因多态性是否与盆腔器官脱垂有关。
研究设计
通过聚合酶链反应，随后进行限制性片段长度多态性分析，确定基质金属蛋白酶-9 基因多态性（rs3918242、rs17576 和 rs2250889）的基因型。
结果
在所评估的基质金属蛋白酶-9 rs17576 基因型分布中，有盆腔器官脱垂和无盆腔器官脱垂的女性之间存在显著差异。使用多变量逻辑回归，绝经状态、基质金属蛋白酶-9 rs17576 基因型 AG 和基质金属蛋白酶-9 rs17576 基因型 GG 与盆腔器官脱垂显著相关。
结论
本研究表明，基质金属蛋白酶-9 rs17576 多态性可能与盆腔器官脱垂有关。
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