Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.
Toxicon. 2010 Dec 15;56(7):1113-9. doi: 10.1016/j.toxicon.2010.01.021. Epub 2010 Feb 6.
Loxoscelism is caused by envenomation by spiders from Loxosceles genus. Clinical symptoms only appear a few hours after envenomation and can evolve in local reactions, such as dermonecrosis, and systemic reactions, such as intravascular haemolysis, intravascular coagulation and renal failure. Current therapies are not effective, often not based in scientific research and can be even detrimental. A lack of understanding of the mechanism of action of the venom of the Loxosceles spider had thus far prevented development of effective therapies. In this review we aim to give an overview of our contributions to the understanding of the mechanism of action of the Loxosceles venom and propose targets and therapeutics for medical intervention.
裂体性蛛毒中毒是由产自 Loxosceles 属的蜘蛛叮咬引起的。临床症状仅在叮咬后数小时出现，并可进展为局部反应（如皮肤坏死）和全身反应（如血管内溶血、血管内凝血和肾衰竭）。目前的治疗方法无效，往往缺乏科学研究依据，甚至可能有害。由于对 Loxosceles 蜘蛛毒液作用机制缺乏了解，因此迄今为止尚未开发出有效的治疗方法。在这篇综述中，我们旨在概述我们对 Loxosceles 毒液作用机制的理解，并提出医学干预的靶点和治疗方法。
