δ-9-四氢大麻酚对皮质类固醇生成的抑制作用。

Inhibition of cortiocosteroidogenesis by delta-9-tetrahydrocannabinol.

作者信息

Warner W, Harris L S, Carchman R A

出版信息

Endocrinology. 1977 Dec;101(6):1815-20. doi: 10.1210/endo-101-6-1815.

PMID:201449

Abstract

ACTH, cholera toxin, cyclic AMP but not pregnenolone-induced steroidogenesis in Y-1 functional mouse adrenal tumor cells was significantly inhibited by delta-9-tetrahydrocannabinol, cannabidiol, and cannabinol. The inhibition of steroidogenesis could not be correlated with a general depression in cell function or viability. The data suggest that cannabinoids inhibit corticosteroidogenesis at a site between the synthesis of cAMP and of pregnenolone.

摘要

促肾上腺皮质激素、霍乱毒素、环磷酸腺苷，但孕烯醇酮诱导的Y-1功能性小鼠肾上腺肿瘤细胞中的类固醇生成，被δ-9-四氢大麻酚、大麻二酚和大麻酚显著抑制。类固醇生成的抑制与细胞功能或活力的普遍降低无关。数据表明，大麻素在环磷酸腺苷和孕烯醇酮合成之间的位点抑制皮质类固醇生成。