Studies of TMPRSS2-ERG gene fusions in diagnostic trans-rectal prostate biopsies.
作者信息
Attard Gerhardt, de Bono Johann S, Clark Jeremy, Cooper Colin S
出版信息
Clin Cancer Res. 2010 Feb 15;16(4):1340; author reply 1340. doi: 10.1158/1078-0432.CCR-09-2253. Epub 2010 Feb 9.
Abstract
摘要
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ERG expression is associated with increased risk of biochemical relapse following radical prostatectomy in early onset prostate cancer.在早发性前列腺癌中，视网膜电图（ERG）表达与根治性前列腺切除术后生化复发风险增加相关。
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The mutational landscape of prostate cancer.前列腺癌的突变全景。
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The complexity of prostate cancer: genomic alterations and heterogeneity.前列腺癌的复杂性：基因组改变和异质性。
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Oncogenic activation of ERG: A predominant mechanism in prostate cancer.ERG的致癌激活：前列腺癌中的主要机制。
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TMPRSS2-ERG status in circulating tumor cells as a predictive biomarker of sensitivity in castration-resistant prostate cancer patients treated with abiraterone acetate.在接受醋酸阿比特龙治疗的去势抵抗性前列腺癌患者中，循环肿瘤细胞中的 TMPRSS2-ERG 状态作为预测生物标志物的敏感性。
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本文引用的文献
1
ETS gene fusions in prostate cancer.ETS 基因融合与前列腺癌。
Nat Rev Urol. 2009 Aug;6(8):429-39. doi: 10.1038/nrurol.2009.127.
2
Prevalence of TMPRSS2-ERG fusion prostate cancer among men undergoing prostate biopsy in the United States.美国接受前列腺活检的男性中TMPRSS2-ERG融合前列腺癌的患病率。
Clin Cancer Res. 2009 Jul 15;15(14):4706-11. doi: 10.1158/1078-0432.CCR-08-2927. Epub 2009 Jul 7.
3
Prostate cancer of transition zone origin lacks TMPRSS2-ERG gene fusion.起源于移行带的前列腺癌缺乏TMPRSS2-ERG基因融合。
Mod Pathol. 2009 Jul;22(7):866-71. doi: 10.1038/modpathol.2009.57. Epub 2009 Apr 24.
4
Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.去势抵抗性前列腺癌患者循环肿瘤细胞中ERG、AR和PTEN基因状态的特征分析
Cancer Res. 2009 Apr 1;69(7):2912-8. doi: 10.1158/0008-5472.CAN-08-3667.
5
Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer.TMPRSS2与ERG序列融合的重复可识别致命性人类前列腺癌。
Oncogene. 2008 Jan 10;27(3):253-63. doi: 10.1038/sj.onc.1210640. Epub 2007 Jul 16.
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