C 反应蛋白基因的变异与急性缺血性脑卒中患者血清 CRP 水平相关。
Variation in the C-reactive protein gene is associated with serum levels of CRP in patients with acute ischemic stroke.
机构信息
Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. m.denhertog @ erasmusmc.nl
出版信息
Cerebrovasc Dis. 2010;29(4):372-5. doi: 10.1159/000281835. Epub 2010 Feb 9.
BACKGROUND AND PURPOSE
Elevated levels of C-reactive protein (CRP) are found in up to three quarters of patients with acute ischemic stroke and are associated with poor outcome. We investigated whether haplotypes representing common variations in the CRP gene are associated with levels of CRP in patients with acute ischemic stroke.
METHODS
We included 185 patients with ischemic stroke in whom CRP was measured within 24 h of symptom onset. Common haplotypes within the CRP gene were determined by 3 genotype-tagging single-nucleotide polymorphisms (SNPs).
RESULTS
Four haplotypes with frequencies >5% covered 99.2% of the genetic variation. Haplotype 4 (CCG, frequency 8.3%) was associated with a 20.6 mg/l (95% CI, 9.8-30.4) stronger increase in CRP level as compared with haplotype 1 (CTC, frequency 33.7%).
CONCLUSION
Variation in the CRP gene is associated with levels of CRP in acute ischemic stroke.
背景与目的
高达四分之三的急性缺血性脑卒中患者的 C 反应蛋白（CRP）水平升高，且其与不良预后相关。我们研究了 CRP 基因常见变异的单体型是否与急性缺血性脑卒中患者的 CRP 水平相关。
方法
我们纳入了 185 例发病 24 h 内接受 CRP 检测的缺血性脑卒中患者。通过 3 个基因型标签单核苷酸多态性（SNP）确定 CRP 基因内的常见单体型。
结果
频率>5%的 4 种单体型涵盖了 99.2%的遗传变异。与单体型 1（CTC，频率 33.7%）相比，单体型 4（CCG，频率 8.3%）的 CRP 水平升高 20.6 mg/L（95%可信区间，9.8-30.4）。
结论
CRP 基因的变异与急性缺血性脑卒中患者的 CRP 水平相关。
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