Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 210029, China.
J Mol Neurosci. 2013 Mar;49(3):559-66. doi: 10.1007/s12031-012-9856-8. Epub 2012 Aug 9.
High-sensitivity C-reactive protein (hsCRP) was reported as a strong, independent predictor of future myocardial infarction and stroke. It is of importance to illustrate the conformance of CRP genetic variation, increment of plasma hsCRP and cerebral events. A case-control study including 548 patients with acute ischemic stroke and 993 age-matched controls from community-based population was conducted and four tagging SNPs (tagSNPs) were genotyped. Multiple logistic regression was applied to evaluate the association of CRP gene and stroke hsCRP elevation with adjustment for covariates. The results indicated that rs3093059 and rs3091244 presented statistical associations with ischemic stroke. Odds ratios (ORs) (95 % confidence interval [CI]) of additive model, dominant model and minor allele at rs3093059 were 0.697 (0.528-0.921), 0.671 (0.487-0.923) and 0.811 (0.666-0.988), and ORs (95 % CI) of dominant model at rs3091244 was 0.728 (0.536-0.988), after adjusting for covariates. But there were no significant differences of genotype or allele frequencies of the four SNPs observed between hypertension (HT) and normal blood pressure (NBP) groups. Further analyses indicated the genetic variations of rs876537 and rs3093059 were positively associated with increased square root transformed hsCRP and hsCRP elevation (≥3 mg/l) in ischemic stroke patients, and rs876537 and rs3091244 were associated with hsCRP elevation in controls as well. Our finding suggests that the CRP genetic polymorphisms were associated with decreased risk of ischemic stroke and elevated plasma hsCRP and further replication study and functional research would be warranted.
高敏 C 反应蛋白（hsCRP）被报道为未来心肌梗死和中风的强有力的独立预测因子。重要的是要说明 CRP 基因变异、血浆 hsCRP 升高与脑事件的一致性。进行了一项包括 548 例急性缺血性中风患者和 993 名年龄匹配的社区人群对照的病例对照研究，并对 4 个标记 SNP（tagSNP）进行了基因分型。应用多元逻辑回归评估 CRP 基因与中风 hsCRP 升高的相关性，并进行了协变量调整。结果表明，rs3093059 和 rs3091244 与缺血性中风呈统计学关联。rs3093059 的加性模型、显性模型和次要等位基因的优势比（OR）（95%置信区间[CI]）分别为 0.697（0.528-0.921）、0.671（0.487-0.923）和 0.811（0.666-0.988），rs3091244 的显性模型的 OR（95%CI）为 0.728（0.536-0.988），调整协变量后。然而，在高血压（HT）和正常血压（NBP）组之间，四个 SNP 的基因型或等位基因频率没有显著差异。进一步的分析表明，rs876537 和 rs3093059 的遗传变异与缺血性中风患者中平方根转化的 hsCRP 和 hsCRP 升高（≥3mg/L）呈正相关，rs876537 和 rs3091244 与对照组的 hsCRP 升高也有关。我们的研究结果表明，CRP 基因多态性与缺血性中风风险降低以及血浆 hsCRP 升高有关，需要进一步的复制研究和功能研究。
