锌在 D-肌醇 1,2,6-三磷酸的抗肿瘤和抗恶病质活性中的作用。
The role of zinc in the anti-tumour and anti-cachectic activity of D-myo-inositol 1,2,6-triphosphate.
机构信息
Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, UK.
出版信息
Br J Cancer. 2010 Mar 2;102(5):833-6. doi: 10.1038/sj.bjc.6605562. Epub 2010 Feb 9.
BACKGROUND
D-myo-inositol-1,2,6-triphosphate (alpha-trinositol, AT) is a polyanionic molecule capable of chelating divalent metal ions with anti-tumour and anti-cachectic activity in a murine model.
METHODS
To investigate the role of zinc in this process, mice bearing cachexia-inducing MAC16 tumour were treated with AT, with or without concomitant administration of ZnSO(4).
RESULTS
At a dose of 40 mg kg(-1), AT effectively attenuated both weight loss and growth of the MAC16 tumour, and both effects were attenuated by co-administration of Zn(2+). The concentration of zinc in gastrocnemius muscle increased with increasing weight loss, whereas administration of AT decreased the levels of zinc in plasma, skeletal muscle and tumour, which were restored back to control values after administration of ZnSO(4).
CONCLUSION
These results suggest that zinc is important in both tumour growth and cachexia in this animal model.
背景
D-肌醇-1,2,6-三磷酸（α-肌醇，AT）是一种多阴离子分子，能够螯合二价金属离子，具有抗肿瘤和抗恶病质活性，在鼠模型中。
方法
为了研究锌在这个过程中的作用，用 AT 治疗患有恶病质诱导的 MAC16 肿瘤的小鼠，同时给予或不给予 ZnSO（4）。
结果
在 40mg/kg 的剂量下，AT 有效地减轻了 MAC16 肿瘤的体重减轻和生长，并且这两种作用都被 Zn（2+）的共给药所减弱。随着体重减轻，腓肠肌中的锌浓度增加，而 AT 给药降低了血浆、骨骼肌和肿瘤中的锌水平，在给予 ZnSO（4）后，这些水平恢复到对照值。
结论
这些结果表明，锌在该动物模型中的肿瘤生长和恶病质中都很重要。
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