多种基因和基因座相互作用与白癜风易感性相关。

Multiple genes and locus interactions in susceptibility to vitiligo.

机构信息

Melanogenix Group, Division of Molecular Genetics and Development, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.

出版信息

J Invest Dermatol. 2010 Mar;130(3):643-5. doi: 10.1038/jid.2009.403.

DOI:10.1038/jid.2009.403

PMID:20145641

Abstract

Refining the position of loci on chromosomes 7 and 9 previously linked with generalized vitiligo or vitiligo-associated autoimmune diseases presenting in families has been performed by high-density single-nucleotide polymorphism (SNP) genotyping. Investigation of the genetic interaction among these loci (and with a previously identified susceptibility gene, NLRP1, on chromosome 17) as risk factors for vitiligo demonstrates the complex nature of this disease.

摘要

通过高密度单核苷酸多态性 (SNP) 基因分型，对先前与家族性泛发性白癜风或伴发自身免疫性疾病的白癜风相关的染色体 7 和 9 上的基因座位置进行了精确定位。对这些基因座（以及先前鉴定的 17 号染色体上的易感性基因 NLRP1）之间的遗传相互作用作为白癜风的风险因素的研究表明，这种疾病具有复杂的性质。