KIT 也能在儿童体内控制肥大细胞。

KIT masters mast cells in kids, too.

机构信息

Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan.

出版信息

J Invest Dermatol. 2010 Mar;130(3):648-50. doi: 10.1038/jid.2009.291.

DOI:10.1038/jid.2009.291

PMID:20145643

Abstract

Adult mastocytosis is usually persistent and caused by c-KIT codon 816-activating mutations. Pediatric mastocytosis is often transient, and the molecular mechanism driving mast cell proliferation in pediatric cases remains unclear. In this issue, Bodemer et al. report novel c-KIT mutations in a large percentage of pediatric cases, identifying both similarities and fundamental differences in the mechanisms causing adult and pediatric mastocytosis.

摘要

成人肥大细胞增多症通常是持续性的，由 c-KIT 密码子 816 激活突变引起。儿童肥大细胞增多症通常是短暂性的，驱动儿科病例中肥大细胞增殖的分子机制仍不清楚。在本期杂志中，Bodemer 等人报道了很大比例的儿科病例中存在新的 c-KIT 突变，确定了导致成人和儿童肥大细胞增多症的机制既有相似之处，也有根本差异。