Unit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Soroka Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84101, Israel.
J Oncol. 2009;2009:581939. doi: 10.1155/2009/581939. Epub 2010 Jan 17.
This review will focus on recent knowledge related to circulating autoantibodies (AAbs) to tumor-associated antigens (TAAs) in epithelial ovarian carcinoma. So far, the following TAAs have been identified to elicit circulating AAbs in epithelial ovarian carcinoma: p53, homeobox proteins (HOXA7, HOXB7), heat shock proteins (HSP-27, HSP-90), cathepsin D, cancer-testis antigens (NY-ESO-1/LAGE-1), MUC1, GIPC-1, IL-8, Ep-CAM, and S100A7. Since AAbs to TAAs have been identified in the circulation of patients with early-stage cancer, it has been speculated that the assessment of a panel of AAbs specific for epithelial ovarian carcinoma TAAs might hold great potential as a novel tool for early diagnosis of epithelial ovarian carcinoma.
这篇综述将重点介绍与上皮性卵巢癌相关的循环肿瘤相关抗原（TAAs）自身抗体（AAbs）的最新知识。迄今为止，已经确定以下 TAAs 在上皮性卵巢癌中引起循环 AAbs：p53、同源盒蛋白（HOXA7、HOXB7）、热休克蛋白（HSP-27、HSP-90）、组织蛋白酶 D、癌睾丸抗原（NY-ESO-1/LAGE-1）、MUC1、GIPC-1、IL-8、Ep-CAM 和 S100A7。由于已经在上皮性卵巢癌早期患者的循环中检测到针对 TAAs 的 AAbs，因此有人推测，评估一组针对上皮性卵巢癌 TAAs 的 AAbs 可能具有作为上皮性卵巢癌早期诊断的新型工具的巨大潜力。
