Du Qiang, Yu Ruofei, Wang Han, Yan Dong, Yuan Qi, Ma Yixin, Slamon Dennis, Hou Dongmei, Wang Huiling, Wang Qi
Department of Respiratory Medicine, The Second Affiliated Hospital, Dalian Medical University, Dalian, China.
Department of Respiratory Medicine, The North Area of Suzhou Municipal Hospital, Suzhou, China.
Clin Respir J. 2018 Jun;12(6):2020-2028. doi: 10.1111/crj.12769. Epub 2018 Feb 15.
Autoantibodies tumor-associated antigens (TAAs) could be a valuable tool for the diagnosis or early detection of cancer due to their relatively high specificity and stability. The purpose of this study is to detect the level of tumor-associated autoantibodies in lung cancer and assess the diagnostic potential of autoantibodies in screening strategy for early stage lung cancer.
Levels of tumor-associated autoantibodies (AAbs) were measured against a panel of seven TAAs (p53, PGP9.5, SOX2, GAGE7, GBU4-5, CAGE and MAGEA1) in 397 patients with pulmonary lesions (305 with newly diagnosis of NSCLC, 47 with SCLC and 45 with benign nodule) and 74 control persons without any nodules in the lung after chest MDCT scan. The sensitivity, specificity for patients and control persons, positive rate of the panel in different pathology, stage, size of lesion, age and gender were compared and analyzed.
The AAbs panel could distinguish malignant lesions from benign lesions and control people, with sensitivity of 56.53% and specificity of 91.60%. The specificity could be further increased to 95.80%, when combined with CT. The AAbs also showed high diagnostic value of malignant nodule, and it would be a new method for judgment of malignant nodules that are less than 8 mm in diameter. No significant differences were seen based on pathology, NSCLC stages, tumor size, age or gender.
This assay confirms the value of AAbs panel as a diagnostic tool combined with CT scan.
肿瘤相关抗原（TAAs）的自身抗体因其相对较高的特异性和稳定性，可能成为癌症诊断或早期检测的宝贵工具。本研究旨在检测肺癌中肿瘤相关自身抗体的水平，并评估自身抗体在早期肺癌筛查策略中的诊断潜力。
对397例肺部病变患者（305例新诊断为非小细胞肺癌、47例小细胞肺癌和45例良性结节）和74例胸部MDCT扫描后肺部无任何结节的对照者，检测针对一组七种TAAs（p53、PGP9.5、SOX2、GAGE7、GBU4-5、CAGE和MAGEA1）的肿瘤相关自身抗体（AAbs）水平。比较并分析该检测对患者和对照者的敏感性、特异性，以及在不同病理、分期、病变大小、年龄和性别的阳性率。
AAbs检测组能够区分恶性病变与良性病变及对照人群，敏感性为56.53%，特异性为91.60%。与CT联合时，特异性可进一步提高到95.80%。AAbs对恶性结节也显示出较高的诊断价值，对于直径小于8mm的恶性结节判断将是一种新方法。在病理、非小细胞肺癌分期、肿瘤大小、年龄或性别方面未见显著差异。
本检测证实了AAbs检测组作为与CT扫描联合使用的诊断工具的价值。
