Cohen D
Tijdschr Psychiatr. 2010;52(2):111-5.
Mortality in schizophrenic patients is clearly higher than in the general population. One of the reasons is the higher prevalence of the lethal side-effects of antipsychotics: diabetic ketoacidosis, prolonged qt-c time and gastro-intestinal hypomotility associated with clozapine are three serious side-effects which sometimes prove fatal. Systematic screening, however, means that sideeffects can be diagnosed at an earlier, less severe stage, leading to higher rates of survival and remission. This should contribute to a normalising of the mortality rate.
精神分裂症患者的死亡率明显高于普通人群。原因之一是抗精神病药物致死性副作用的发生率较高:糖尿病酮症酸中毒、QT - c间期延长以及与氯氮平相关的胃肠道动力不足是三种严重的副作用,有时会导致死亡。然而,系统筛查意味着可以在副作用较轻的早期阶段进行诊断,从而提高生存率和缓解率。这应该有助于使死亡率正常化。