Pediatric Neuro-Oncology at Pediatrics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Pediatr Blood Cancer. 2010 Apr;54(4):641-3. doi: 10.1002/pbc.22375.
High-grade or malignant glioma represent 10% of pediatric brain tumors and are, taken as a whole, the second more frequent malignant histotype after medulloblastoma. Apart from a complete excision followed by full dose local radiotherapy, chemotherapy seems to give some beneficial to final outcome. Different trials have explored the role of high-dose chemotherapy that theoretically could give an advantage to these patients by overcoming blood-brain barrier, tumor cell chemo-resistance and inducing a wider number of responses. It is, however, still doubtful if better responses translate into improved outcome and which patients can have a true beneficial from this treatment strategy.
高级别或恶性神经胶质瘤占儿童脑肿瘤的 10%，作为一个整体，是继髓母细胞瘤之后第二常见的恶性组织学类型。除了完全切除后进行全剂量局部放疗外，化疗似乎对最终结果有一定的益处。不同的试验已经探讨了大剂量化疗的作用，理论上通过克服血脑屏障、肿瘤细胞化疗耐药性和诱导更多的反应，可以使这些患者受益。然而，更好的反应是否能转化为更好的结果，以及哪些患者可以从这种治疗策略中真正受益，仍然存在疑问。
