Sichuan University, Chengdu, People's Republic of China.
IUBMB Life. 2010 Mar;62(3):170-5. doi: 10.1002/iub.289.
In 2006, it was reported that transgenic expression of merely four defined transcription factors (c-Myc, Klf4, Oct4, and Sox2) is sufficient to reprogram somatic cells to a pluripotent state. The resulting induced pluripotent stem (iPS) cells ignited intense interest in the field of life science for their promising applications in basic biology, drug development, and transplantation. However, the underlying problems of iPS cells seem to be ignored. This review shed light on the problems pertaining iPS cells, including the elusive origin, risk of tumorgenesis, and its relationship with natural selection.
2006 年有报道称，仅仅转导表达 4 种定义明确的转录因子（c-Myc、Klf4、Oct4 和 Sox2）就足以将体细胞重编程为多能状态。由此产生的诱导多能干细胞（iPS 细胞）在基础生物学、药物开发和移植等领域的应用前景非常广阔，这在生命科学领域引起了强烈的兴趣。然而，iPS 细胞的潜在问题似乎被忽视了。本综述探讨了与 iPS 细胞相关的问题，包括其来源不明、致瘤风险及其与自然选择的关系。
