来自克拉玛尔红树林种子的柠檬苦素和三萜烷衍生物，Xylocarpus moluccensis。

Limonoids and tirucallane derivatives from the seeds of a krishna mangrove, Xylocarpus moluccensis.

机构信息

Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, People's Republic of China.

出版信息

J Nat Prod. 2010 Apr 23;73(4):644-9. doi: 10.1021/np900823c.

DOI:10.1021/np900823c

PMID:20146503

Abstract

Six new phragmalins, moluccensins H-M (1-6), two new andirobin-type limonoids, moluccensins N and O (7, 8), and two new tirucallane derivatives, moluccensins P and Q (9, 10), were isolated from seeds of an Indian mangrove, Xylocarpus moluccensis, together with the known compound 3beta,22S-dihydroxytirucalla-7,24-dien-23-one. The structures of these compounds were established on the basis of spectroscopic data. Moluccensins H-L were phragmalins with a C-30 carbonyl group, and moluccensin M was a unique ring-D-opened 16-norphragmalin. Moluccensins H-J possess conjugated Delta(8,9) and Delta(14,15) double bonds, moluccensins K and L contain a Delta(8,14) double bond, and moluccensin M has a characteristic C(15)-C(30) linked five-membered lactone ring. Moluccensins H and I showed moderate insecticidal activity against the fifth instar larvae of Brontispa longissima (Gestro) at a concentration of 100 mg/L.

摘要

从印度红树林 Xylocarpus moluccensis 的种子中分离得到了六种新的菲拉马林，即 moluccensins H-M（1-6），两种新的和irobin 型柠檬苦素，即 moluccensins N 和 O（7,8），以及两种新的三萜衍生物，moluccensins P 和 Q（9,10），此外还有已知化合物 3β,22S-二羟基三萜烯-7,24-二烯-23-酮。这些化合物的结构是基于光谱数据确定的。Moluccensins H-L 是具有 C-30 羰基的菲拉马林，而 moluccensin M 是一种独特的环-D 开环 16-诺菲拉马林。Moluccensins H-J 具有共轭的 Delta(8,9)和 Delta(14,15)双键，Moluccensins K 和 L 含有 Delta(8,14)双键，而 moluccensin M 具有特征性的 C(15)-C(30)连接的五元内酯环。Moluccensins H 和 I 在 100mg/L 浓度下对第五龄 Brontispa longissima（Gestro）幼虫表现出中等的杀虫活性。