胸腺来源的天然调节性 T 细胞的发育。
Development of thymically derived natural regulatory T cells.
机构信息
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, USA.
出版信息
Ann N Y Acad Sci. 2010 Jan;1183:1-12. doi: 10.1111/j.1749-6632.2009.05129.x.
Abstract
Natural regulatory T cells (nTregs) are defined by their inherent ability to establish and maintain peripheral self-tolerance. In recent years, the development of nTregs has come under close examination with the advent of Forkhead Box P3 protein (FOXP3)-green fluorescent protein reporter mice that pinpointed the initiation of FOXP3 expression within the thymus. The mechanism and pathway of nTreg development has only recently been studied in detail and to a large degree remains unclear. In this review, we will discuss our current understanding of nTreg lineage choice and development from a cellular and intracellular standpoint.
摘要
天然调节性 T 细胞（nTregs）的定义是其固有能力，可建立和维持外周自身耐受。近年来，随着叉头框 P3 蛋白（FOXP3）-绿色荧光蛋白报告小鼠的出现，nTregs 的发展受到了密切关注，该小鼠确定了 FOXP3 在胸腺内的表达起始。nTreg 发育的机制和途径最近才被详细研究，在很大程度上仍不清楚。在这篇综述中，我们将从细胞和细胞内的角度讨论我们对 nTreg 谱系选择和发育的现有认识。
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