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Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling.强力的 CD28 共刺激抑制通过 Lck 信号通路从幼稚前体诱导调节性 T 细胞。
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Foxo transcription factors control regulatory T cell development and function.Foxo 转录因子控制调节性 T 细胞的发育和功能。
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Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3.DNA 结合抑制因子 Id3 对调节性 T 细胞和 T(H)17 细胞分化的调控。
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自然和诱导调节性 T 细胞发育的细胞和分子决定因素。

Cellular and molecular determinants for the development of natural and induced regulatory T cells.

机构信息

Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, FL 33136, United States.

出版信息

Hum Immunol. 2012 Aug;73(8):773-82. doi: 10.1016/j.humimm.2012.05.010. Epub 2012 Jun 1.

DOI:10.1016/j.humimm.2012.05.010
PMID:22659217
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3410644/
Abstract

Regulation of immune responses to self and foreign antigens is critically dependent on suppressive CD4(+) T cells characterized by expression of Foxp3. The large majority of regulatory T (Treg) cells develop in the thymus as a stable suppressive lineage. However, under the proper physiological conditions, conventional peripheral CD4(+) T lymphocytes also develop into Treg cells, particularly in the gut mucosa and inflammatory tissue sites. This review will focus on our current understanding of the immunological and molecular signals controlling the development of thymic derived natural (n)Treg and peripheral converted induced (i)Treg cells. Given the importance of Foxp3 in the development of these cells, particular attention is placed on how such signals are integrated to induce and maintain the expression of this signature transcriptional regulator of Treg cells.

摘要

免疫应答对自身和外来抗原的调节，严重依赖于表达 Foxp3 的抑制性 CD4(+) T 细胞。大多数调节性 T（Treg）细胞在胸腺中作为一种稳定的抑制性谱系发育。然而，在适当的生理条件下，常规外周 CD4(+) T 淋巴细胞也可发育成 Treg 细胞，特别是在肠道黏膜和炎症组织部位。这篇综述将重点介绍我们目前对控制胸腺衍生天然（n）Treg 和外周转化诱导（i）Treg 细胞发育的免疫和分子信号的理解。鉴于 Foxp3 在这些细胞发育中的重要性，特别关注这些信号如何整合以诱导和维持 Treg 细胞的这种特征性转录调节剂的表达。