Chen Y, Zhang Y, Zhu Y-L, Fu P-L
Department of Orthopaedics, Changzheng Hospital, Second Military Medical University, Shanghai, China.
J Int Med Res. 2009 Nov-Dec;37(6):1733-41. doi: 10.1177/147323000903700609.
Eighty patients with osteoarthritis who underwent unilateral total knee arthroplasty were randomly assigned to two groups: the trial group received an intra-operative intra-articular injection of magnesium sulphate and ropivacaine, and the control group received an injection of normal saline. All patients received patient-controlled analgesia with morphine for 48 h post-operatively. It was found that an intra-articular injection of magnesium sulphate and ropivacaine significantly reduced morphine consumption during the 0 - 24 h post-operative period and total 48-h post-operative morphine consumption. Pain scores at rest and during motion in the trial group were significantly lower than in the controls during the first 24 h post-operatively. The time to be able to perform a straight leg raise and to reach a 90 degrees knee flexion was significantly shorter in the trial group compared with the controls. This study demonstrated that an intra-operative intra-articular magnesium sulphate and ropivacaine injection reduced the use of post-operative morphine.
80例行单侧全膝关节置换术的骨关节炎患者被随机分为两组：试验组术中接受关节腔内注射硫酸镁和罗哌卡因，对照组接受生理盐水注射。所有患者术后48小时接受吗啡自控镇痛。结果发现，关节腔内注射硫酸镁和罗哌卡因可显著减少术后0至24小时的吗啡用量以及术后48小时的吗啡总用量。术后头24小时内，试验组静息和活动时的疼痛评分显著低于对照组。与对照组相比，试验组能够进行直腿抬高和达到膝关节90度屈曲的时间显著缩短。本研究表明，术中关节腔内注射硫酸镁和罗哌卡因可减少术后吗啡的使用。
