Floating Hospital for Children, Tufts Medical Center, United States.
Autoimmun Rev. 2010 May;9(7):507-10. doi: 10.1016/j.autrev.2010.02.011. Epub 2010 Feb 8.
Vitamin D levels depend on many variables, including sun exposure, age, ethnicity, body mass index, use of medications and supplements. A much higher oral vitamin D intake than the current guidelines is necessary to maintain adequate circulating 25(OH)D levels in the absence of UVB radiation of the skin. In addition to the traditional known metabolic activities, vitamin D has been shown to modulate the immune system, and its deficiency has been linked to the development of several autoimmune disorders including type 1 diabetes and multiple sclerosis. Experimental use of vitamin D has revealed a novel role in the immunopathogenesis of autoimmune diseases. Disorders such as systemic lupus erythematosus, rheumatoid arthritis, Behçet's, polymyositis/dermatomyositis and systemic scleroderma have all been associated to some extent to vitamin D deficiency. If vitamin D deficiency occurs at a higher rate in patients with autoimmune disorders, then appropriate supplementation may be indicated.
维生素 D 水平取决于许多变量，包括阳光照射、年龄、种族、体重指数、药物和补充剂的使用。在没有皮肤紫外线 B 辐射的情况下，为了维持足够的循环 25(OH)D 水平，需要比目前的指南建议更高的口服维生素 D 摄入量。除了传统的已知代谢活性外，维生素 D 已被证明可以调节免疫系统，其缺乏与包括 1 型糖尿病和多发性硬化症在内的几种自身免疫性疾病的发展有关。维生素 D 的实验应用揭示了其在自身免疫性疾病的免疫发病机制中的新作用。红斑狼疮、类风湿关节炎、贝切特病、多发性肌炎/皮肌炎和系统性硬皮病等疾病在某种程度上都与维生素 D 缺乏有关。如果自身免疫性疾病患者的维生素 D 缺乏发生率更高，那么适当的补充可能是必要的。
