Başarslan Fatmagül, Kaba İlknur
Pediatrics, Hitit University, Çorum, TUR.
Cureus. 2022 Nov 30;14(11):e32064. doi: 10.7759/cureus.32064. eCollection 2022 Nov.
Recurrent aphthous stomatitis is one of the most common oral mucosal diseases. It is characterized by recurrent painful attacks. Its etiology is unknown. Vitamin D (vit D) is a steroid vitamin with immunomodulatory and anti-inflammatory effects. It is thought that oral cavity diseases may occur in vitamin D deficiency. This study aimed to investigate vit D levels in pediatric patients with recurrent aphthous stomatitis.
In this retrospective study, 86 children with recurrent aphthous stomatitis and 71 age-matched healthy children were included in the study. The 25-hydroxyvitamin D levels examined with the enzyme immune assay were recorded for both groups.
Serum vit D level was 12±4.5 ng/ml in the group with aphthous stomatitis and 31±7 ng/ml in the healthy group. A statistically significant difference was found in vit D levels between the two groups (p<0.001).
Vit D levels were significantly low in children with recurrent aphthous stomatitis. Our findings suggest that low vit D levels may be associated with recurrent aphthous stomatitis.
复发性阿弗他口炎是最常见的口腔黏膜疾病之一。其特征为反复发作的疼痛。病因不明。维生素D（vit D）是一种具有免疫调节和抗炎作用的类固醇维生素。人们认为维生素D缺乏可能会引发口腔疾病。本研究旨在调查复发性阿弗他口炎患儿的维生素D水平。
在这项回顾性研究中，86名复发性阿弗他口炎患儿和71名年龄匹配的健康儿童被纳入研究。两组均记录了通过酶免疫测定法检测的25-羟基维生素D水平。
阿弗他口炎组的血清维生素D水平为12±4.5 ng/ml，健康组为31±7 ng/ml。两组之间的维生素D水平存在统计学上的显著差异（p<0.001）。
复发性阿弗他口炎患儿的维生素D水平显著较低。我们的研究结果表明，低维生素D水平可能与复发性阿弗他口炎有关。
