Lalaiants I E, Milovanova L S
Vopr Onkol. 1991;37(2):206-10.
A hypothesis presented in the paper discusses the role of valine substitution in p21 protein of H-ras, a product of ras family oncogene. The event was followed by a marked decrease in GTPase activity of the protein and alteration of its function in the cell. Recent results of X-ray structural analysis were compared with the model suggested by the authors earlier. The role of valine substitution in sickle-cell anemia held to be a genetic mechanism of protection against malaria is discussed. Based on similarity of valine substitution in p21 protein and hemoglobin, a relationship between certain forms of malignant transformation and malaria at molecular level is suggested.
该论文中提出的一个假说探讨了缬氨酸替代在H-ras的p21蛋白中的作用，H-ras是ras家族致癌基因的一个产物。这一事件之后，该蛋白的GTPase活性显著下降，其在细胞中的功能也发生了改变。将X射线结构分析的最新结果与作者之前提出的模型进行了比较。讨论了缬氨酸替代在镰状细胞贫血中作为预防疟疾的遗传机制的作用。基于p21蛋白和血红蛋白中缬氨酸替代的相似性，提出了某些形式的恶性转化与疟疾在分子水平上的关系。
