Ito O, Suzaki H, Nomura Y
Department of Otolaryngology, University of Tokyo, Japan.
Acta Otolaryngol. 1991;111(1):144-8. doi: 10.3109/00016489109137365.
The distribution of fibronectin (FN) in operative specimens of maxillary sinus mucosa from 35 patients with chronic sinusitis was examined immunohistochemically. Mouse monoclonal antibody to human FN was used for the peroxidase-antiperoxidase staining technique. FN was found in most of the serous cells and in some (about 10%) of the mucous cells in the nasal glands, and also in the nasal fluid in the lumina. It was not found elsewhere, be it in the epithelial cells, the basement membrane, or the interstitial tissue, except in two patients. These results suggest that FN is produced in the nasal glands and secreted into the nasal fluid in the maxillary sinus in chronic sinusitis.
采用免疫组织化学方法检测了35例慢性鼻窦炎患者上颌窦黏膜手术标本中纤连蛋白（FN）的分布情况。使用抗人FN的小鼠单克隆抗体进行过氧化物酶-抗过氧化物酶染色技术。在鼻腺的大多数浆液细胞以及部分（约10%）黏液细胞中发现了FN，在管腔的鼻液中也有发现。除两名患者外，在上皮细胞、基底膜或间质组织中均未发现。这些结果表明，在慢性鼻窦炎中，FN是在鼻腺中产生并分泌到上颌窦的鼻液中的。
