睾酮在新生鹌鹑大脑中招募新的芳香化酶免疫反应性细胞。
Testosterone recruits new aromatase-imunoreactive cells in neonatal quail brain.
作者信息
Bardet Sylvia M, Cornil Charlotte A, Balthazart Jacques
机构信息
GIGA Neurosciences, Research Group in Behavioral Neuroendocrinology, University of Liège, Liège, Belgium.
出版信息
Neuroreport. 2010 Mar 31;21(5):376-80. doi: 10.1097/WNR.0b013e3283378edf.
Abstract
It was shown earlier that, in Japanese quail the mechanism controlling the induction by testosterone of aromatase activity develops between embryonic days 10 and 14. The cellular processes underlying this activation have, however, not been investigated in detail. Here, we demonstrate that the increase in aromatase activity observed in neonates treated with testosterone propionate between postnatal days 1 and 3 results from the recruitment of additional populations of aromatase-immunoreactive cells that were not expressing the enzyme at detectable levels before. This recruitment concerns all brain nuclei normally expressing the enzyme even if it is more prominent in the ventromedial hypothalamus than in other nuclei.
摘要
早期研究表明，在日本鹌鹑中，控制睾酮诱导芳香化酶活性的机制在胚胎第10至14天之间发育。然而，这种激活背后的细胞过程尚未详细研究。在这里，我们证明，出生后第1至3天用丙酸睾酮处理的新生鹌鹑中观察到的芳香化酶活性增加，是由于招募了额外的芳香化酶免疫反应性细胞群体，这些细胞在之前未检测到可表达该酶的水平。这种招募涉及所有正常表达该酶的脑核，即使在腹内侧下丘脑比在其他核中更明显。
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