Genomics and Stress Laboratory, Instituto de Tecnologia Química e Biológica, Avenida da República, 2780-157 Oeiras, Portugal.
Yeast. 2010 May;27(5):245-58. doi: 10.1002/yea.1752.
The budding yeast Saccharomyces cerevisiae possesses a very flexible and complex programme of gene expression when exposed to several environmental challenges. Homeostasis is achieved through a highly coordinated mechanism of transcription regulation involving several transcription factors, each one acting singly or in combination to perform specific functions. Here, we review our current knowledge of the function of the Yap transcription factors in stress response. They belong to b-ZIP proteins comprising eight members with specificity at the DNA-binding domain distinct from that of the conventional yeast AP-1 factor, Gcn4. We finish with new insights into the links of transcriptional networks controlling several cellular processes. The data reviewed in this article illustrate how much our comprehension of the biology of Yap family involved in stress response has advanced, and how much research is still needed to unravel the complexity of the role of these transcriptional factors. The complexities of these regulatory interactions, as well as the dynamics of these processes, are important to understand in order to elucidate the control of stress response, a highly conserved process in eukaryotes.
当酵母暴露于多种环境挑战时，它具有非常灵活和复杂的基因表达调控程序。通过涉及多个转录因子的高度协调的转录调控机制来实现内稳态，每个转录因子单独或组合发挥特定功能。在这里，我们回顾了 Yap 转录因子在应激反应中的功能的现有知识。它们属于 b-ZIP 蛋白家族，包含 8 个成员，其 DNA 结合域的特异性与传统的酵母 AP-1 因子 Gcn4 不同。最后，我们探讨了控制多个细胞过程的转录网络之间的联系。本文综述的研究数据说明了我们对参与应激反应的 yap 家族生物学的理解已经取得了多大的进展，以及为了阐明这些转录因子的复杂作用还需要进行多少研究。这些调控相互作用的复杂性以及这些过程的动态性对于理解应激反应的控制至关重要，这是真核生物中高度保守的过程。
