Dirier A, Burhanedtin-Zincircioglu S, Karadayi B, Isikdogan A, Aksu R
Department of Radiation Oncology, Gaziantep University Medical Faculty, Gaziantep, Turkey.
J BUON. 2009 Oct-Dec;14(4):619-23.
Women under 40 years of age comprise a small proportion of patients with breast cancer. Clinical and pathological features of the disease in these patients are different from those in older patients with this type of cancer. In the present study we investigated the clinicopathological characteristics and prognostic factors in young patients with breast cancer.
We retrospectively reviewed the medical records of 249 consecutive breast cancer patients who were admitted to our department between August 2001 and December 2005. Clinicopathological features were determined both in patients under and over 40 years of age.
106 (42.5%) patients were under and 143 (57.5%) were over 40 years. The mean age was 35.2 years for those under 40 years and 54 for those older than 40 years. At diagnosis, 10.4% of the patients in the younger age group and 7.0% in the older age group had metastasis (p=0.500). Patients in the younger age group exhibited higher estrogen receptor (ER) negativity (48.1 vs. 37.1%) (p=0.425) and a higher percentage of family history of breast cancer (4.7 vs. 2.8%) (p=0.651). Breast cancer in younger women was more frequently associated with other poor prognostic factors such as perineural and/or lymphovascular invasion. The 5-year overall survival was 6.3% for the younger patients and 22.2% for the older ones (p=0.004).
This study demonstrates that breast cancer in younger patients has significantly more poor prognostic features compared to older ones.
40岁以下女性在乳腺癌患者中占比小。这类患者的疾病临床和病理特征与老年乳腺癌患者不同。在本研究中，我们调查了年轻乳腺癌患者的临床病理特征及预后因素。
我们回顾性分析了2001年8月至2005年12月期间连续收治入本科的249例乳腺癌患者的病历。确定了40岁以下和40岁以上患者的临床病理特征。
106例（42.5%）患者年龄在40岁以下，143例（57.5%）患者年龄在40岁以上。40岁以下患者的平均年龄为35.2岁，40岁以上患者的平均年龄为54岁。诊断时，较年轻年龄组10.4%的患者和较年长年龄组7.0%的患者发生转移（p = 0.500）。较年轻年龄组患者雌激素受体（ER）阴性率更高（48.1%对37.1%）（p = 0.425），且乳腺癌家族史比例更高（4.7%对2.8%）（p = 0.651）。年轻女性乳腺癌更常与其他不良预后因素相关，如神经周围和/或淋巴管浸润。年轻患者的5年总生存率为6.3%，老年患者为22.2%（p = 0.004）。
本研究表明，与老年患者相比，年轻患者的乳腺癌具有明显更多的不良预后特征。
