新兴纳米技术在艾滋病治疗和预防中的应用。
Emerging nanotechnology approaches for HIV/AIDS treatment and prevention.
机构信息
Laboratory of Nanomedicine and Biomaterials, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
出版信息
Nanomedicine (Lond). 2010 Feb;5(2):269-85. doi: 10.2217/nnm.10.1.
Abstract
Currently, there is no cure and no preventive vaccine for HIV/AIDS. Combination antiretroviral therapy has dramatically improved treatment, but it has to be taken for a lifetime, has major side effects and is ineffective in patients in whom the virus develops resistance. Nanotechnology is an emerging multidisciplinary field that is revolutionizing medicine in the 21st century. It has a vast potential to radically advance the treatment and prevention of HIV/AIDS. In this review, we discuss the challenges with the current treatment of the disease and shed light on the remarkable potential of nanotechnology to provide more effective treatment and prevention for HIV/AIDS by advancing antiretroviral therapy, gene therapy, immunotherapy, vaccinology and microbicides.
摘要
目前，艾滋病既没有治愈方法，也没有预防疫苗。联合抗逆转录病毒疗法显著改善了治疗效果，但必须终身服用，且具有重大副作用，对于病毒产生耐药性的患者无效。纳米技术是一个新兴的多学科领域，正在彻底改变 21 世纪的医学。它具有极大的潜力，可以通过推进抗逆转录病毒疗法、基因疗法、免疫疗法、疫苗学和杀微生物剂，从根本上改善艾滋病的治疗和预防。在这篇综述中，我们讨论了当前疾病治疗所面临的挑战，并阐明了纳米技术通过推进抗逆转录病毒疗法、基因疗法、免疫疗法、疫苗学和杀微生物剂，为艾滋病提供更有效治疗和预防的显著潜力。
相似文献
1
Emerging nanotechnology approaches for HIV/AIDS treatment and prevention.新兴纳米技术在艾滋病治疗和预防中的应用。
Nanomedicine (Lond). 2010 Feb;5(2):269-85. doi: 10.2217/nnm.10.1.
2
A review of nanotechnological approaches for the prophylaxis of HIV/AIDS.纳米技术在预防 HIV/AIDS 中的应用综述。
Biomaterials. 2013 Aug;34(26):6202-28. doi: 10.1016/j.biomaterials.2013.05.012. Epub 2013 May 28.
3
Gene-based immunotherapy for human immunodeficiency virus infection and acquired immunodeficiency syndrome.基于基因的人类免疫缺陷病毒感染和获得性免疫缺陷综合征免疫疗法。
Hum Gene Ther. 2006 Jun;17(6):577-88. doi: 10.1089/hum.2006.17.577.
4
Toward a cure - Advancing HIV/AIDs treatment modalities beyond antiretroviral therapy: A Review.迈向治愈——超越抗逆转录病毒疗法的 HIV/AIDS 治疗模式的进展：综述。
Medicine (Baltimore). 2024 Jul 5;103(27):e38768. doi: 10.1097/MD.0000000000038768.
5
Nanotechnology approaches to eradicating HIV reservoirs.纳米技术方法根除 HIV 储库。
Eur J Pharm Biopharm. 2019 May;138:48-63. doi: 10.1016/j.ejpb.2018.06.002. Epub 2018 Jun 4.
6
Role of nanotechnology in HIV/AIDS treatment: potential to overcome the viral reservoir challenge.纳米技术在艾滋病毒/艾滋病治疗中的作用：克服病毒储存库挑战的潜力。
Discov Med. 2006 Aug;6(34):157-62.
7
Clinical challenges in HIV/AIDS: Hints for advancing prevention and patient management strategies.艾滋病防治的临床挑战：推进预防和患者管理策略的启示。
Adv Drug Deliv Rev. 2016 Aug 1;103:5-19. doi: 10.1016/j.addr.2016.04.016. Epub 2016 Apr 23.
8
[HIV/AIDS: the new therapeutic strategies remain a priority].[艾滋病毒/艾滋病：新的治疗策略仍是当务之急]
Rev Med Suisse. 2009 Nov 11;5(225):2301-2.
9
[Implementation of a continuum of care for people living with HIV/AIDS in Hanoi (Vietnam)].[越南河内为艾滋病毒/艾滋病感染者提供连续护理的实施情况]
Sante. 2009 Jul-Sep;19(3):141-8. doi: 10.1684/san.2009.0169.
10
The economics of HIV/AIDS in low-income countries: the case for prevention.低收入国家的艾滋病毒/艾滋病经济学：预防的理由。
J Econ Perspect. 2006 Summer;20(3):121-42. doi: 10.1257/jep.20.3.121.
引用本文的文献
1
Advances in HIV Treatment and Vaccine Development: Emerging Therapies and Breakthrough Strategies for Long-Term Control.艾滋病治疗与疫苗研发进展：新兴疗法及长期控制的突破性策略
AIDS Res Treat. 2025 Jul 4;2025:6829446. doi: 10.1155/arat/6829446. eCollection 2025.
2
State-of-art high-performance Nano-systems for mutated coronavirus infection management: From Lab to Clinic.用于突变型冠状病毒感染管理的前沿高性能纳米系统：从实验室到临床。
OpenNano. 2022 Nov-Dec;8:100078. doi: 10.1016/j.onano.2022.100078. Epub 2022 Sep 10.
3
Polymeric and lipidic nanoparticles in transforming anti-HIV combinational therapy: can they turn the tide?聚合物和脂质纳米颗粒在抗HIV联合治疗中的转化应用：它们能否扭转局面？
Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr 23. doi: 10.1007/s00210-025-04169-w.
4
HIV Cerebrospinal Fluid Escape: Interventions for the Management, Current Evidence and Future Perspectives.HIV脑脊液逃逸：管理干预措施、当前证据及未来展望
Trop Med Infect Dis. 2025 Feb 5;10(2):45. doi: 10.3390/tropicalmed10020045.
5
Nanotechnology-based approaches for targeted drug delivery for the treatment of respiratory tract infections.基于纳米技术的靶向给药方法用于治疗呼吸道感染。
J Biol Methods. 2024 Oct 23;11(4):e99010032. doi: 10.14440/jbm.2024.0065. eCollection 2024.
6
Navigating Latency-Inducing Viral Infections: Therapeutic Targeting and Nanoparticle Utilization.应对潜伏期诱导性病毒感染：治疗靶点与纳米颗粒的应用
Biomater Res. 2024 Oct 16;28:0078. doi: 10.34133/bmr.0078. eCollection 2024.
7
Inhibition of HIV-1 infection with curcumin conjugated PEG-citrate dendrimer; a new nano formulation.姜黄素偶联聚乙二醇-柠檬酸树枝状聚合物抑制 HIV-1 感染：一种新的纳米制剂。
BMC Complement Med Ther. 2024 Oct 2;24(1):350. doi: 10.1186/s12906-024-04634-8.
8
Advances in the transdermal delivery of antiretroviral drugs.抗逆转录病毒药物经皮给药的进展
SAGE Open Med. 2024 Jan 18;12:20503121231223600. doi: 10.1177/20503121231223600. eCollection 2024.
9
Drug Delivery to the Brain: Recent Advances and Unmet Challenges.药物向脑内的递送：最新进展与未解决的挑战
Pharmaceutics. 2023 Nov 23;15(12):2658. doi: 10.3390/pharmaceutics15122658.
10
Advances in drug delivery systems, challenges and future directions.药物递送系统的进展、挑战与未来方向。
Heliyon. 2023 Jun 24;9(6):e17488. doi: 10.1016/j.heliyon.2023.e17488. eCollection 2023 Jun.
本文引用的文献
1
The immune response during acute HIV-1 infection: clues for vaccine development.急性 HIV-1 感染期间的免疫反应：疫苗开发的线索。
Nat Rev Immunol. 2010 Jan;10(1):11-23. doi: 10.1038/nri2674. Epub 2009 Dec 11.
2
Amphiphilic poly{[alpha-maleic anhydride-omega-methoxy-poly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery.两亲性聚{[α-马来酸酐-ω-甲氧基-聚（乙二醇）]-共-（乙基氰基丙烯酸酯）}接枝共聚物纳米粒作为经皮给药载体。
Int J Nanomedicine. 2009;4:227-32. doi: 10.2147/ijn.s7814. Epub 2009 Oct 19.
3
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier.可快速穿透人体黏液屏障的可生物降解聚合物纳米颗粒。
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19268-73. doi: 10.1073/pnas.0905998106. Epub 2009 Nov 9.
4
All-trans retinoic acid potentiates the antibody response in mice to a lipopeptide antigen adjuvanted with liposomal lipid A.全反式维 A 酸增强了脂肽抗原与脂质 A 脂质体佐剂在小鼠中的抗体应答。
Immunol Cell Biol. 2009 Nov-Dec;87(8):630-3. doi: 10.1038/icb.2009.48. Epub 2009 Jul 14.
5
NanoART, neuroAIDS and CNS drug delivery.纳米医学、神经艾滋病与中枢神经系统药物递送
Nanomedicine (Lond). 2009 Jul;4(5):557-74. doi: 10.2217/nnm.09.38.
6
Macrophage delivery of nanoformulated antiretroviral drug to the brain in a murine model of neuroAIDS.在神经艾滋病小鼠模型中，巨噬细胞将纳米配方抗逆转录病毒药物递送至大脑。
J Immunol. 2009 Jul 1;183(1):661-9. doi: 10.4049/jimmunol.0900274. Epub 2009 Jun 17.
7
Immunotherapies in HIV-1 infection.HIV-1感染中的免疫疗法。
Curr Opin HIV AIDS. 2009 May;4(3):188-93. doi: 10.1097/COH.0b013e328329d090.
8
X-ray structures of the hexameric building block of the HIV capsid.人类免疫缺陷病毒衣壳六聚体构建模块的X射线结构。
Cell. 2009 Jun 26;137(7):1282-92. doi: 10.1016/j.cell.2009.04.063. Epub 2009 Jun 11.
9
AIDS vaccine research and advocacy: an update.艾滋病疫苗研究与宣传：最新进展
BETA. 2009 Winter-Spring;21(2):24-30.
10
Patent life of antiretroviral drugs approved in the US from 1987 to 2007.1987年至2007年在美国获批的抗逆转录病毒药物的专利寿命。
AIDS Care. 2009 Jun;21(6):760-8. doi: 10.1080/09540120802511950.
Zotero 插件