Laboratory of Nanomedicine and Biomaterials, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Nanomedicine (Lond). 2010 Feb;5(2):269-85. doi: 10.2217/nnm.10.1.
Currently, there is no cure and no preventive vaccine for HIV/AIDS. Combination antiretroviral therapy has dramatically improved treatment, but it has to be taken for a lifetime, has major side effects and is ineffective in patients in whom the virus develops resistance. Nanotechnology is an emerging multidisciplinary field that is revolutionizing medicine in the 21st century. It has a vast potential to radically advance the treatment and prevention of HIV/AIDS. In this review, we discuss the challenges with the current treatment of the disease and shed light on the remarkable potential of nanotechnology to provide more effective treatment and prevention for HIV/AIDS by advancing antiretroviral therapy, gene therapy, immunotherapy, vaccinology and microbicides.
目前,艾滋病既没有治愈方法,也没有预防疫苗。联合抗逆转录病毒疗法显著改善了治疗效果,但必须终身服用,且具有重大副作用,对于病毒产生耐药性的患者无效。纳米技术是一个新兴的多学科领域,正在彻底改变 21 世纪的医学。它具有极大的潜力,可以通过推进抗逆转录病毒疗法、基因疗法、免疫疗法、疫苗学和杀微生物剂,从根本上改善艾滋病的治疗和预防。在这篇综述中,我们讨论了当前疾病治疗所面临的挑战,并阐明了纳米技术通过推进抗逆转录病毒疗法、基因疗法、免疫疗法、疫苗学和杀微生物剂,为艾滋病提供更有效治疗和预防的显著潜力。