Infertility and IVF Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tiqwa, Israel.
Gynecol Endocrinol. 2010 Mar;26(3):187-92. doi: 10.3109/09513590903015601.
To compare the results of IVF cycles following coasting in patients treated with long versus short GnRH agonist protocols.
A retrospective comparative study in which all women aged 35 years or less attending the IVF unit from 2000 to 2006 in whom coasting was used in GnRH agonist protocols were included. Data on coasting-related variables and outcome were collected from the files and compared between the short GnRH agonist (n = 78) and long GnRH agonist (n = 181) cycles.
The short GnRH agonist cycles were characterized by higher E2 levels during coasting and longer duration of coasting than the long GnRH agonist cycles. Although the number of retrieved oocytes was lower following coasting in the short protocol, there was no difference between the groups in fertilization rate, number of high-quality embryos available for transfer, and pregnancy rate. Pregnancy rate in both protocols was negatively correlated to E2 level at initiation of coasting. The overall moderate and severe OHSS rate after coasting was 5.1% in the short-protocol group and 6.0% in the long-protocol group (p = 0.76).
The ovarian response curve to coasting is longer in the short than in the long GnRH-agonist protocol, but there is no significant difference in pregnancy or OHSS rates.
比较长方案和短方案中使用黄体期降调节（coasting）的 IVF 周期结果。
这是一项回顾性对比研究，纳入了 2000 年至 2006 年在我们生殖医学中心接受 IVF 治疗且年龄均小于等于 35 岁的患者。收集了与 coasting 相关的变量和结局数据，并对短 GnRH 激动剂（n = 78）和长 GnRH 激动剂（n = 181）周期进行了比较。
短 GnRH 激动剂周期在 coasting 期间 E2 水平更高， coasting 持续时间更长。尽管短方案 coasting 后获卵数较低，但两组间受精率、可移植的优质胚胎数和妊娠率均无差异。两个方案的妊娠率均与 coasting 起始时的 E2 水平呈负相关。短方案和长方案 coasting 后中重度卵巢过度刺激综合征（OHSS）的总体发生率分别为 5.1%和 6.0%（p = 0.76）。
短 GnRH 激动剂方案中卵巢对 coasting 的反应曲线比长方案更长，但妊娠率和 OHSS 发生率无显著差异。
