Rosenn Barak M
Department of Obstetrics & Gynecology, St. Luke's Roosevelt Hospital Center, 1000 10th Ave., Suite 10-C, New York, NY10019, USA.
J Matern Fetal Neonatal Med. 2010 Mar;23(3):219-23. doi: 10.3109/14767050903550873.
Over the past decade, several studies have been published describing the use of glyburide for the treatment of women with gestational diabetes (GDM). These studies include randomized prospective trials, prospective studies, and cohort studies. With a total of more than 1000 patients, they encompass a wide range of patient populations and treatment centers and demonstrate the effectiveness of oral treatment in achieving good glycemic control in women with GDM. Taken together, these studies have demonstrated that glyburide is as safe and as useful as insulin for the treament of women with GDM and will likely become universally accepted as the first line drug of choice for treatment of this condition.
在过去十年中，已发表了几项关于使用格列本脲治疗妊娠期糖尿病（GDM）女性的研究。这些研究包括随机前瞻性试验、前瞻性研究和队列研究。这些研究共有1000多名患者，涵盖了广泛的患者群体和治疗中心，并证明了口服治疗在实现GDM女性良好血糖控制方面的有效性。总体而言，这些研究表明，格列本脲在治疗GDM女性方面与胰岛素一样安全且有效，很可能会被普遍接受为治疗这种疾病的一线首选药物。
