Das Abhijit, Reichert Heinrich, Rodrigues Veronica
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
J Neurogenet. 2010 Mar;24(1):42-53. doi: 10.3109/01677060903582202.
Diverse neuronal cell types arise from the lateral neuroblast in the antennal lobe of Drosophila. The authors show that loss of Notch function from the entire lineage during development leads to an absence of local interneurons (LNs) with a concomitant increase in the number of projection neurons (PNs). The presence of the intracellular domain of Notch was observed within the nucleus of newly born neurons within the neuroblast lineage. This leads to the suggestion that Notch acts in a binary fate decision to determine formation of LNs and PNs, resulting in two distinct hemilineages from the single neuroblast. The observation of nuclear Notch in several neuroblast lineages leads us to speculate that this mechanism is widespread during the developing Drosophila brain.
多种神经元细胞类型起源于果蝇触角叶中的外侧神经母细胞。作者表明，在发育过程中整个谱系中Notch功能的丧失会导致局部中间神经元（LN）缺失，同时投射神经元（PN）数量增加。在神经母细胞谱系中新生神经元的细胞核内观察到了Notch的细胞内结构域。这表明Notch在二元命运决定中起作用，以确定LN和PN的形成，从而从单个神经母细胞产生两个不同的半谱系。在几个神经母细胞谱系中观察到核内的Notch，这使我们推测这种机制在果蝇大脑发育过程中广泛存在。
