Department of Dermatology, Liverpool Hospital, Sydney, New South Wales 2170, Australia.
Australas J Dermatol. 2010 Feb;51(1):60-5. doi: 10.1111/j.1440-0960.2009.00610.x.
A 41-year-old Phillipino man presented with a 3-year history of a relapsing and remitting generalized chronic pruritic erythematous papular and plaque-like eruption. Investigations showed a persistently elevated eosinophil count. His disease was limited to cutaneous involvement with an absence of demonstrable internal organ involvement, despite extensive investigations and multidisciplinary review. Other causes of eosinophilia were excluded. A diagnosis of idiopathic hypereosinophilic syndrome was made. Our patient's presentation raises a number of issues related to hypereosinophilic syndrome. In particular, relating to managing hypereosinophilic syndrome and the challenge of minimizing therapy side-effects. Our case highlights the considerable morbidity of untreated isolated cutaneous disease, for which he was hospitalized with suicidal ideations. In a minority of reports, skin involvement is the only manifestation of hypereosinophilic syndrome.
一位 41 岁的菲律宾男性，患有反复发作和缓解的全身性慢性瘙痒性红斑丘疹和斑块状皮疹，病史 3 年。检查显示嗜酸性粒细胞计数持续升高。尽管进行了广泛的检查和多学科评估，但他的疾病仅限于皮肤受累，没有明显的内脏器官受累。排除了其他嗜酸性粒细胞增多症的原因。诊断为特发性嗜酸性粒细胞增多综合征。我们患者的表现提出了与嗜酸性粒细胞增多症相关的许多问题。特别是与管理嗜酸性粒细胞增多症和最小化治疗副作用的挑战有关。我们的病例强调了未经治疗的孤立性皮肤疾病的相当大的发病率，为此他因自杀意念住院治疗。在少数报告中，皮肤受累是嗜酸性粒细胞增多症的唯一表现。
